Abstract
The immunoglobulin heavy chain (IgH) component of antibodies contains a variable region composed of variable (VH), diversity (D) and joining (JH) gene segments. The combinatorial rearrangement of these gene segments enables immune cells to produce a huge variety of antibodies. The human VH gene segments comprise seven families: VH1-VH7. Several types of B cell malignancies exhibit preferential VH family usage. For example, pediatric acute lymphoblastic leukemia frequently uses the …
Full Text 
Sign-in/Register to access full text options
Sign-in/Register to access full text options 
Published version (
Free)
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
