Abstract
Intralipid (IL) infusion in healthy adults has resulted in decreased pulmonary diffusing capacity (DLCO) and arterial(a) PO2. To assess the pulmonary effects of IL, 0.4 gm/kg of IL was infused over 1 hour into 9 adult rabbits whose lungs had been damaged by a prior infusion of 0.15 cc/kg of oleic acid. Triglyceride (TG) levels were significantly elevated at 1 hour and remained significantly above baseline despite Heparin infusion of 200 units/kg at 2 hours, 1 hour after IL infusion.There were no significant changes in pH, PaCO2 or alveolar(A)-arterial CO2 difference [P(A-a)CO2]. The PaO2 and P(a-A)O2 were significantly worse at peak TG levels but then progressively improved to baseline level or better despite only partial TG recovery. Although the immediate changes suggest that IL should not be administered to patients with lung disease, the subsequent TG-unrelated recovery indicates that chronic IL administration does not impair gas exchange. In fact, by an entirely different and as yet unexplained mechanism, pulmonary gas exchange may even be enhanced with chronic IL infusion.
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