976-11 Cyclical Variation in the Occurrence of Paroxysmal Supraventricular Tachycardia in Female Patients

Abstract

The aim of the present study was to assess the presence of cyclical variations of episodes of supraventricular tachycardia (SVT) in female patients (pts) and to correlate their occurrence with the cyclical variation in the plasma levels of ovarian hormones. The study population included 26 (mean age 36 ± 8) female pts with episodes of SVT. included in the study were those with at least 3 episodes of SVT in 2 consecutive ambUlatory ECG monitoring and regular menses (AEM). Thirteen patients (mean age 32 ± 6) met the study criteria and entered the study. Pts underwent 48 hour AEM and determination of plasma concentrations of estradiol 17 β and progesterone on day 7, 14,21 and 28 of their menstrual cycle. Day7 Day 14 Day 21 Day 28 Heart Rate 72 ± 9 73 ± 13 76 ± 9 76 ± 14 No episodes 28 25 36 49 * Duration 12 ± 14 12 ± 11 21 ± 14 27 ± 11 * Class Lawn >2 3 3 2 9 * * p < 0.05 Day 28 compared to day7 A significant positive correlation was found between plasma concentrations of progesterone and number and duration of SVT (r 2 = 0.81, P < 0.05 and r 2 = 0.78. P < 0.05, respectively) while a significant inverse correlation was found between plasma concentrations of estradiol 17 β and number an duration of SVT (r 2 = -0.91, P < 0.05, r2 = 0.67, P < 0.05, respectively). In conclusion female pts with SVT and normal menses exhibit a cyclical variation in the occurrence of the episodes of SVT with their menses and a close correlation between the episodes of SVT and the plasma concentrations of ovarian hormones. These data suggest that changes in plasma levels of ovarian hormones (and their balance) may be of importance in determining episodes of SVT in such patients.