#97 : Can Platelet Rich Plasma (PRP) Improve Human Ejaculated Sperm Quality? A Systematic Review and Meta Analysis

Abstract

Background and Aims: Males are found contribute to 50% of infertility cases overall. Abnormal sperm parameters, such as low concentration, low motility, or abnormally morphology is thought to play a major role in male infertility. In many recent studies, Platelet Rich Plasma (PRP) was reported to have potential therapeutic effect. PRP with its rich growth factor composition, has already proven beneficial in regenerative therapy. PRP can improve the structural and functional impairment of the testis, thereby improve the sperm quality as its product. This study aims to identify the improvement of ejaculated sperm concentration, motility, morphology after treatment with PRP. Methods: A systematic search was conducted in PubMed, Cochrane and Google Scholar databases up to November 2022. We used Prisma’s checklist 2020 as a guideline for writing this. To be included in this meta-analysis, eligible studies had to be a clinical trial comparing ejaculated sperm with PRP treatment and no PRP addition. We conducted both quantitative and qualitative analysis of the assessed outcomes. Results: A total of 91 studies were retrieved. After excluding ineligible publication, 5 studies were finally included in the present meta-analysis (n=331). Among them, varied methods of PRP intervention, but all of them had using PRP 2%. By using a random effect model, there is an improvement of the progressive sperm in group with PRP treatment (MD 15,00, 95%-CI 6,71-23,29). Quantitative analysis (meta-analysis) was not carried out for sperm concentration and morphology, but was explained descriptively, that sperm concentration and morphology increased after PRP treatment. The articles included in the analysis have a low risk of bias. Conclusions: There is an improvement in sperm progressivity after treatment with PRP, that also means there is an improvement in human ejaculated sperm quality. Although found beneficial enhancing the sperm progressivity, but still needed strong evidence for further research.