96-P

Abstract

Human Leukocyte Antigens (HLA), which is extremely polymorphic, plays an important role in stem cell transplantation. The Chinese Han comprise a large population of approximate 1.3 billion with diverse HLA alleles need to be characterized. Data from 3296 independent, unrelated Chinese Han individuals (1457 recipients and 1839 donors) were provided by China Marrow Donor Program (CMDP) for donor-recipient confirmatory typing. SBT, SSOP/HD-SSOP and SSP methods were used to obtain 4-digit alleles. A total of 49, 86, 50, 63 and 24 HLA-A, B, C, DRB1, and DQB1 alleles were observed. Following ASHI CWD criteria, CWD alleles for Chinese Han in our laboratory test and other laboratory reports do not quite correlate with the ASHI CWD alleles: A ∗ 11:53, A ∗ 02:34, A ∗ 02:53N, B ∗ 27:24, B ∗ 46:02, B ∗ 55:12, C ∗ 01:06, C ∗ 03:17, C ∗ 06:06, C ∗ 07:66, C ∗ 07:67, C ∗ 08:22, DRB1 ∗ 12:10, DQB1 ∗ 03:13 and DQB1 ∗ 06:05 are CWD, but are not included in the ASHI CWD list. A series of alleles are Well-Documented alleles and listed in the ASHI CWD list. Conversely, A ∗ 26:03, B ∗ 51:03, C ∗ 12:05, C ∗ 15:09, C ∗ 15:11, C ∗ 17:03, DRB1 ∗ 11:07, DRB1 ∗ 11:11, DRB1 ∗ 13:05, DRB1 ∗ 13:13, DRB1 ∗ 14:06, DRB1 ∗ 14:12, DRB1 ∗ 14:22, DRB1 ∗ 14:25 and DQB1 ∗ 06:11 are rare alleles, but are included in the ASHI CWD list. HLA Ethnic diversity is the main reason for the differences in HLA alleles worldwide. The ASHI HLA CWD alleles help reduce the workload and expenses in high-resolution donor registries and the HLA allele frequencies provide a basis from which to predict the chances of finding HLA matching donors. Our data will be meaningful for the CMDP, for other worldwide donor registries, and for an updated ASHI CWD alleles list.