Abstract
5 medical centers provided 90 children with definite JDMS who had the characteristic skin rash and 3 or 4 criteria: symmetrical proximal muscle weakness, positive muscle biopsy, abnormal EMG, and serum elevation of muscle enzymes. 67 white children had an increase in HLA-DR3, relative risk 3.91, corrected p<.002. Increased HLA-B8, relative risk 2.88, corrected p<.005 was also found. A marginal decrease in HLA-B7 was seen, relative risk 0.20, uncorrected p<.01, corrected p<.20. Their sera was examined for immune complexes Raji and Clq, and antibody to thyroid microsomes, gastric parietal cells, smooth muscle, striated muscle, nuclei, DNA, ENA, RNP, Sm and Pm-1. Only ANA and Raji values were significantly increased, p<.001, above controls. Positive sera occurred with equal frequency in those with HLA-B8 or DR3 as in children without those antigens. Supported by grants from MAIMDD & Ill. Chapter of Arthritis Foundation.
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