Abstract

Regorafenib is a standard therapy for patients with unresectable hepatocellular carcinoma (uHCC) after progression on sorafenib. However, there is no known reliable factor predictive of clinical outcomes for regorafenib. Serum alpha-fetoprotein (AFP) was reported as a significant predictive factor for the outcome of patients with advanced HCC on sorafenib treatment. In this multinational retrospective cohort study, implication of serum alpha-fetoprotein (AFP) in the prediction of effectiveness of regorafenib in uHCC was investigated.

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