Abstract
Pulmonary vascular resistance (PVR) and the trans-pulmonary gradient (TPG) are variables which have been traditionally used to determine the degree of pulmonary vascular remodeling in patients with end stage systolic heart failure. As these variables are impacted by changes in cardiac output and loading conditions, it has been suggested that the diastolic pressure gradient (DPG) may be able to better differentiate patients with fixed versus reversible increases in pulmonary vascular tone. We hypothesized that patients with high pre-operative diastolic pulmonary gradients would continue to have elevated diastolic pressure gradients immediately after left ventricular assist device (LVAD) implantation.
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