Abstract
Liver cancer has a poor prognosis predominantly resulting from tumour heterogeneity and limited treatment options. The two predominant types of liver cancer are Hepatocellular carcinoma (HCC) and Intrahepatic Cholangiocarcinoma (iCCA). CD44v6, a splice variant of the hyaluronic acid receptor CD44, is a marker for cancer stem cells, and is known to impact tumour formation and metastasis in several cancers. The expression of CD44v6 dramatically increases in liver epithelial cells upon carcinogen exposure.
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