948-P: Serum Elabela Is Associated with Inflammatory Abnormalities in Gestational Diabetes Mellitus

Abstract

Gestational diabetes mellitus (GDM) is a common disease in pregnant women, which mechanisms remain unclear. Apelin-APJ system contributes to the energy homeostasis in middle and terminal pregnancy. Elabela (ELA) is another endogenous ligand of apelin receptor (APJ), which is expressed highly in the placenta. Few studies have focused on the role of ELA in GDM and the association between ELA and inflammatory cytokines. In this study we mainly compare the concentrations of serum Elabela between 33 diabetes pregnant women (GDM group) with 33 healthy pregnant women (control group). The inflammatory biomarkers including IL-1β, IL-6 and TNF-α were measured and evaluated the relationship with ELA. There were significant differences in serum Elabela (P<0.05), fasting plasma glucose (FPG), one-hour glucose, two-hour glucose in the OGTT (P<0.001), HOMA-IR (P<0.001), cytokine IL-1β(P<0.05) between GDM group and control group. ELA had significant correlations with FPG (r=-0.254, P=0.039), fasting insulin (r=-0.258, P=0.036), HOMA-IR (r=-0.275, P=0.026), and IL-1β (r=-0.789, P=0.000). And stepwise multiple linear regression analysis presented IL-1β and FPG most significantly affected the ELA levels. This study showed that decreased ELA levels were significantly associated with increased glucose levels and insulin resistance in GDM, which might be mediated by inflammatory factors, such as IL-1β. Serum ELA levels might be a clinical biomarker for GDM. Disclosure Y. Chen: None. M. Shi: None. H. Zhang: None. Funding National Natural Science Foundation of China (81200595, 81400807)