944 LONG-TERM OUTCOME ANALYSIS IN 21 PATIENTS WITH INGUINOSCROTAL SARCOMAS

Abstract

You have accessJournal of UrologyPenis/Testis/Urethra: Benign & Malignant Disease (III)1 Apr 2013944 LONG-TERM OUTCOME ANALYSIS IN 21 PATIENTS WITH INGUINOSCROTAL SARCOMAS Michael Froehner, Rebecca Schober, Rainer Koch, and Manfred Wirth Michael FroehnerMichael Froehner Dresden, Germany More articles by this author , Rebecca SchoberRebecca Schober Dresden, Germany More articles by this author , Rainer KochRainer Koch Dresden, Germany More articles by this author , and Manfred WirthManfred Wirth Dresden, Germany More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2013.02.523AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES To determine long-term outcome data in a sample of these rare tumors. METHODS 21 patients with sarcomas primarily arising in the inguinoscrotal region treated during a 20-year period were studied. Kaplan-Meier curves and competing risk cumulative mortality curves were calculated to evaluate overall and disease-specific survival rates. RESULTS The following histopathological subtypes were observed: leiomyosarcoma (n=8), liposarcoma (n=7), malignant fibrous histiocytoma (n=4), rhabdomyosarcoma (n=2). Eight tumors (38 %) were high grade sarcomas. All patients were initially treated surgically. Until now, two patients died of the disease resulting in a 10-year disease-specific survival rate of 93 %. One of them died from tumor progression 18 years after initial diagnosis. Until now, four patients developed local recurrence. No patients with liposarcoma (all were low grade) experienced disease recurrence. Up to now, retroperitoneal recurrence occurred in three patients and was controlled by radiotherapy in one. The other two patients received palliative radiotherapy, chemotherapy and palliative resection and repeated resection with curative intent (including repeated removal of lung and retroperitoneal metastases), respectively. All three patients with retroperitoneal recurrence were alive 10 years after removal of the primary tumor. CONCLUSIONS This rare tumor entity is characterized by an overall excellent long-term survival but also by the risk of intractable disease recurrence even after long disease-free intervals. Repeat interventions to remove or inactivate recurrent tumors or metastases may be necessary and may provide clinical benefit in individual cases. © 2013 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 189Issue 4SApril 2013Page: e388 Advertisement Copyright & Permissions© 2013 by American Urological Association Education and Research, Inc.MetricsAuthor Information Michael Froehner Dresden, Germany More articles by this author Rebecca Schober Dresden, Germany More articles by this author Rainer Koch Dresden, Germany More articles by this author Manfred Wirth Dresden, Germany More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...