94 Development of systemic lupus erythematosus symptoms is associated with cigarette smoking

Abstract

Background Smoking is associated with the development of aCCP positive rheumatoid arthritis. The association between smoking and SLE is more uncertain. 1) We wanted to compare SLE patients smoking habits before symptom development with population controls. Methods 306 SLE patients fulfilling ACR classification criteria from Oslo area were sent a questionnaire in 2010 regarding smoking. Antibody profiles were collected from medical records. Year of first symptom was defined by the patient, or if the doctors time of the first SLE symptom was earlier, this year was used. Juvenile SLE was defined by start of symptom before 16 years of age. One pack year was 20 cigarettes daily in one year. The proportion smokers in the Norwegian population were found online 2) and every SLE patient was matched with population controls for the year of the first symptom, age (number not available for every years of age, but 10 year groups) and gender. Results 255/306 (80%) SLE patients responded to the questionnaire. The mean age in 2010 was 48 years old (SD 15, min 18 max 98) There were 39 patients with juvenile SLE whereof 64% were never smokers and 4/39 (10%) were smoking at the time of the 1. symptom. Among adult SLE, 116 (42%) were never smokers and 83 (35%) were previous smokers. In year 2010 53 (22%) SLE patients were still smoking vs 20% in the control population (ns). 109/216 (50%) adult SLE patients were smoking at the time of the first SLE symptom vs 35% in the matched control population (p Ever smokers did not have more dsDNA, aSm or aRNP antibodies, but they had a tendency to more discoid lupus (17% vs 8%). Conclusions Even though prevalent SLE patients do not smoke more than their population controls, SLE patients are more often smokers at the time of the first symptom, especially in the higher age groups. This might indicate smoking as an environmental risk factor for developing SLE. However, smoking is tightly related to several other socioeconomic and cultural factors which must be explored in a prospective manner. Funding Source(s): None