93P Migrating cancer stem cell elimination by disrupting tumor-stroma crosstalk using CXCR4 targeting human endogenous peptides in PDAC

K Tiwary,M Harms,B Beitzinger,R Schmid,S Inaas,A Lahusen,K Walter,A Kleger,T Seufferlein,M Lindén,J Münch,P.C Hermann

doi:10.1016/j.annonc.2022.09.094

93P Migrating cancer stem cell elimination by disrupting tumor-stroma crosstalk using CXCR4 targeting human endogenous peptides in PDAC

K Tiwary, M Harms + Show 10 more

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https://doi.org/10.1016/j.annonc.2022.09.094

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Journal: Annals of oncology : official journal of the European Society for Medical Oncology	Publication Date: Oct 1, 2022
License type: publisher-specific-oa

Affiliation: University Hospital Ulm, UL (Germany), University of Ulm

#Pancreatic Ductal Adenocarcinoma #Subset Of Cancer Stem Cells + Show 8 more

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Abstract

Pancreatic ductal adenocarcinoma (PDAC) is one of the most metastatic malignancies worldwide. We previously identified a distinct subset of cancer stem cells within the invasive front of patient tumors called migrating cancer stem cells (miCSCs), characterized by CD133+CXCR4+ expression. It determines the metastatic phenotype of pancreatic cancer. Therefore, targeting CXCR4 represent a potential therapeutic approach to combat metastasis in PDAC.

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