939: Maternal history of cancer, perinatal outcomes and offspring health: Results of a Population Based Cohort

Abstract

Maternal history of malignancies diagnoses and treatment, although becoming more prevalent, are rare conditions which present in 0.1% of parturient. Not much is known about the effect of maternal previous history of malignancies diagnoses and treatment on their offspring. We aimed to study the association between history of malignancy diagnosis and treatment, pregnancy outcomes, and offspring morbidities during childhood. A population based cohort analysis was performed comparing newborn characteristics of mothers with and without history of malignancies diagnosis and treatment. Offspring pediatric hospitalization rates, up to the age of 18 years, were also compared between the groups. Data were collected from the perinatal and pediatric databases of a single tertiary center, the sole center in the region. All singleton deliveries between the years 1991-2014 were included in the analysis, and cases with congenital malformations excluded. Multivariable models were used to address confounding characteristics on the association between the defined exposure and outcomes. During the study period, 243,682 newborns met the inclusion criteria, 149 (0.1%): were born to mothers with a history of cancer diagnosis and treatment. While incidence of small for gestational age (4.6% vs. 5.4%) and low Apgar at 5 minutes (1.3% vs. 2.3%) were not statistically different between the study groups, higher rates of low birthweight (LBW, < 2,500 gr) were found among mothers with vs. without history of cancer (10.1% vs. 6.7%; age and pregnancy complication adjusted odds ratio=1.72; 1.01-2.95). Offspring pediatric hospitalizations rates, due to any causes, were not different between the two study groups (Table and Graph, presenting the comparison of all cause hospitalization between the study groups). Offspring of mothers with a history of malignancy diagnoses and treatment are at increased risk for LBW. However, this was not associated with increased hospitalization rates during childhood.