935 OUTCOME OF BUCCAL MUCOSA GRAFT URETHROPLASTY AFTER RADIATION THERAPY

Abstract

You have accessJournal of UrologyPenis/Testis/Urethra: Benign & Malignant Disease III1 Apr 2012935 OUTCOME OF BUCCAL MUCOSA GRAFT URETHROPLASTY AFTER RADIATION THERAPY Marie-Christine Kuhl, Roland Dahlem, Miriam Traumann, Marianne Schmid, Hendrik Isbarn, Philipp Reiss, Margit Fisch, and Sascha Ahyai Marie-Christine KuhlMarie-Christine Kuhl Hamburg, Germany More articles by this author , Roland DahlemRoland Dahlem Hamburg, Germany More articles by this author , Miriam TraumannMiriam Traumann Hamburg, Germany More articles by this author , Marianne SchmidMarianne Schmid Hamburg, Germany More articles by this author , Hendrik IsbarnHendrik Isbarn Hamburg, Germany More articles by this author , Philipp ReissPhilipp Reiss Hamburg, Germany More articles by this author , Margit FischMargit Fisch Hamburg, Germany More articles by this author , and Sascha AhyaiSascha Ahyai Hamburg, Germany More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2012.02.1032AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES To assess the outcome of buccal mucosa graft urethroplasty (BMGU) for the treatment of urethral strictures in patients with a previous prostate cancer (Pca) related radiation therapy (RTX). METHODS The endpoint of our study was to determine the success rate (stricture recurrence free survival) after BMGU in such individuals. Patients were evaluated by maximum (Qmax) and average (Qaver) flow rate. Recurrence was defined as maximum flow rate < 15 ml/s and identification of urethral narrowing in retrograde urethrography. Pre- and postoperative continence and Quality of live (QoL) was measured by pad test and standardized non validated questionnaire. RESULTS We identified 26 men who underwent BMGU at our institution for urethral strictures after radiation therapy. Six of the patients were excluded from analysis due to death (n=2) or loss to FU (n=4). Mean age was 69,5 years and mean FU was 9,5 months. In 75% treated strictures were located in the bulbomembranous urethra and less < 6 cm in length. According to Kaplan Meier Analysis the success rate of BMGU was at 25 months of FU 60%. Postoperatively, Qmax and Qaver increased from a median of 8.4 to 25.6 ml/s and 3 to 11 ml/s respectively (p<0.07). In patients without stricture recurrence 73% described their urinary stream as never or only rarely decreased after BMGU. Most patients (65 %) after radiation therapy suffered from incontinence before the BMGU. Worsening of incontinence or de-novo incontinence after BMGU was found in 29% and 10% respectively. QoL increased a lot or at least a little after BMGU in 74 % of the treated patients. CONCLUSIONS Success rate of BMGU for urethral stricture in patients who underwent PCa related RTX seems acceptable. Despite some degree of deterioration of continence, most of the patients are satisfied with the result. © 2012 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 187Issue 4SApril 2012Page: e380 Advertisement Copyright & Permissions© 2012 by American Urological Association Education and Research, Inc.MetricsAuthor Information Marie-Christine Kuhl Hamburg, Germany More articles by this author Roland Dahlem Hamburg, Germany More articles by this author Miriam Traumann Hamburg, Germany More articles by this author Marianne Schmid Hamburg, Germany More articles by this author Hendrik Isbarn Hamburg, Germany More articles by this author Philipp Reiss Hamburg, Germany More articles by this author Margit Fisch Hamburg, Germany More articles by this author Sascha Ahyai Hamburg, Germany More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...