Abstract
Accordingly, high number of these cells provided significant survival advantage (p = 0.0391 and p = 0.0136 for intraand peritumoral infiltration, respectively). Furthermore, combination of peritumoral B-cell density with the number of activated T lymphocytes identified patient subgroups with different disease outcome, which was most favorable in the case of high density, while very poor in the case of low density of both cell types. Multivariate survival analysis involving B-cell and activated T-cell densities alone and in combinations, as well as traditional prognostic factors, identified tumour thickness and CD20/OX40 cell density combination as significant independent prognostic factors. Conclusions:Our results show correlation between low numbers of CD20 B lymphocytes and melanoma progression. Moreover, the density of these cells, especially in association with that of activated T lymphocytes, proved of prognostic significance, indicating a possible role of tumour-infiltrating B cells in antitumour immune response reflected in better outcome of the disease.
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