#931 Clinical implications of spatial intra-tumoural heterogeneity on homologous recombination deficiency scores in high grade serous ovarian cancer

Abstract

Introduction/BackgroundHigh-grade serous ovarian cancer (HGSOC) is typified by extensive genomic instability and intra-tumoural heterogeneity (ITH). Most patients relapse and eventually acquire resistance to platinum- or PARP inhibitor-based therapy. Diverse mechanisms...