Abstract

The facilitatory effect of vasopressin neuropeptides on social recognition of adult male rats was analyzed. The decrease of social investigation behaviors during a second encounter with the same juvenile rat served as index for social recognition. Treatment with desglycinamide-(Arg8)-vasopressin (6 mg·kg−1, s.c.) extended the time that adults recognize the same juvenile from 30 min to 24 h. Structure-activity studies revealed that the effect of vasopressin neuropeptides on social recognition resides in the 5–8 part of the AVP molecule. The peptide (pGlu4,Cyt6) AVP-(4–8) was more potent than DGAVP in this behavioral paradigm. These effects bear similarities with the memory enhancing effects of vasopressin neuropeptides as found in other test procedures.

Full Text
Paper version not known

Talk to us

Join us for a 30 min session where you can share your feedback and ask us any queries you have

Schedule a call

Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.