Abstract
The facilitatory effect of vasopressin neuropeptides on social recognition of adult male rats was analyzed. The decrease of social investigation behaviors during a second encounter with the same juvenile rat served as index for social recognition. Treatment with desglycinamide-(Arg8)-vasopressin (6 mg·kg−1, s.c.) extended the time that adults recognize the same juvenile from 30 min to 24 h. Structure-activity studies revealed that the effect of vasopressin neuropeptides on social recognition resides in the 5–8 part of the AVP molecule. The peptide (pGlu4,Cyt6) AVP-(4–8) was more potent than DGAVP in this behavioral paradigm. These effects bear similarities with the memory enhancing effects of vasopressin neuropeptides as found in other test procedures.
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