92 PROSTATE CANCER RISK VARIANTS ASSOCIATED WITH SUSCEPTIBILITY TO OTHER MALIGNANCIES

Abstract

You have accessJournal of UrologyProstate Cancer: Basic Research I1 Apr 201092 PROSTATE CANCER RISK VARIANTS ASSOCIATED WITH SUSCEPTIBILITY TO OTHER MALIGNANCIES Brian T. Helfand, Stacy Loeb, Donghui Kan, Joshua J. Meeks, Brian Le, Matthias D. Hofer, Jessica A. Banks, Phillip R. Cooper, and William J. Catalona Brian T. HelfandBrian T. Helfand Chicago, IL More articles by this author , Stacy LoebStacy Loeb Baltimore, MD More articles by this author , Donghui KanDonghui Kan Chicago, IL More articles by this author , Joshua J. MeeksJoshua J. Meeks Chicago, IL More articles by this author , Brian LeBrian Le Chicago, IL More articles by this author , Matthias D. HoferMatthias D. Hofer Chicago, IL More articles by this author , Jessica A. BanksJessica A. Banks Chicago, IL More articles by this author , Phillip R. CooperPhillip R. Cooper Chicago, IL More articles by this author , and William J. CatalonaWilliam J. Catalona Chicago, IL More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2010.02.141AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES There are now >50 known genetic variants that contribute to prostate cancer (CaP) susceptibility. Prior studies have demonstrated associations between several of these genetic regions with breast, colorectal, and bladder cancers. However, the inter-relationship between CaP, other malignancies, and the genetic variants remains to be determined. Therefore, we investigated the association between the genetic risk variants and the risk of other malignancies in CaP patients. We also examined the relationship of genetic variants in CaP patients to the frequency of other malignancies in first-degree relatives. METHODS The genotypes of 14 CaP susceptibility variants along chromosomes 2p15, 3q21, 5p15, 8q24, 10q11, 11q13, 17q12, 17q24, 19q13.2, and Xp11 were determined for 473 patients with CaP. Statistical analysis was used to compare the frequencies of the genetic variants in patients whose only tumor was CaP to those with CaP and other malignancies. In addition, we compared the frequency of genetic variants in CaP patients with a first-degree family history of another malignancy, versus those without a family history of other cancers. RESULTS Among patients treated for CaP, 11.6%, 0.9%, and 0.6% reported a personal history of skin cancer, lymphoma/leukemia, and colon cancer, respectively. Men who were carriers of the variants along 10q11 (p=0.03) and 17q24 (p=0.008) were significantly more likely to have colon and hematologic cancers, respectively. In comparison, the variants along chromosomes 3q21 (p=0.0002) and Xp11 (p=0.04) had an inverse relationship with the development of skin cancers. The data obtained in the family history part of the study revealed carriers of the rs16901979 variant along 8q24 with CaP were significantly (p=0.02) more likely to have a first-degree relative with colon cancer. Finally, carriers of variants along 5p15 (p=0.05) and 19q13 (p=0.0008) with CaP were significantly more likely to have a first-degree relative with skin cancer. CONCLUSIONS Previous reports have implicated an increased frequency of other malignancies in CaP patients. However, the genetic mechanisms underlying these associations have remained elusive. We report an association between the CaP susceptibility variants and an increased frequency of colon cancer and hematologic malignancies, and a decreased frequency of other cancers. In addition, specific genetic variants appear to be associated with a family history of colon and skin cancers. © 2010 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 183Issue 4SApril 2010Page: e38 Advertisement Copyright & Permissions© 2010 by American Urological Association Education and Research, Inc.MetricsAuthor Information Brian T. Helfand Chicago, IL More articles by this author Stacy Loeb Baltimore, MD More articles by this author Donghui Kan Chicago, IL More articles by this author Joshua J. Meeks Chicago, IL More articles by this author Brian Le Chicago, IL More articles by this author Matthias D. Hofer Chicago, IL More articles by this author Jessica A. Banks Chicago, IL More articles by this author Phillip R. Cooper Chicago, IL More articles by this author William J. Catalona Chicago, IL More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...