916 Activation of Energy Sensor – AMPK Reverses Impairment of Angiogenesis in Aging Gastric Mucosa. Underlying Molecular Mechanisms are: Activation of AMPK, Induction of Importin α and Activation of VEGF Gene.

Abstract

transferred the same number of colitogenic Ly5.1(+) and Ly5.2(+) CD4(+) T cells from lamina propria (LP) of colitic CD4(+)CD45RB(high) T cell-transferred RAG-2(-/-) and colitic IL-10(-/-) mice, respectively, into RAG-2(-/-) mice. Surprisingly, the co-transferred RAG2(-/-) mice showed the vast cellular infiltration of LP CD4(+) T cells like RAG-2(-/-) mice re-transferred with the cells from the colitic RAG-2(-/-) mice alone, but without wasting like RAG-2(-/-) mice transferred with the cells from colitic IL-10(-/-) mice alone. Furthermore, both the ratio of Th1 and Th17 cells originated from IL-10(-/-) mice and the ratio of Th1 cells from colitic RAG-2(-/-) mice significantly decreased as compared to the paired RAG2(-/-) mice. Conclusions: Collectively, all the present results suggest that there exist “Th1 vs. Th17 competition” and their orchestration appeared as a merged clinical phenotype of the colitis of two different colitic mice.