91 Surfactant Lung Lavage and Inhaled Nitric Oxide in The Treatment of Meconium Aspiration Syndrome 1- Influence on Oxygenation

Abstract

The aim of study was to evaluate the efficacy of treatment of severe meconium aspiration syndrome/MAS/complicated with persistent pulmonary hypertension/PPHN/in the improvement of oxygenation. The designed therapeutic approach consisted of surfactant lung lavage/SLL/and surfactant instillation together with Nitric Oxide inhalation/iNO/. The study population was randomized into two groups: group A/n= 7/treated with SLL, surfactant instillation and iNO, and group B/n= 6/treated with surfactant instillation and iNO. Criteria for inclusion: maturity >35 weeks of gestation, time after delivery < 24 hours, presence of fluid containing meconium below vocal cords, respiratory insufficiency demanding mechanical ventilation/Fi0240%/, radiological changes, and echocardiographic features of pulmonary hypertension.