Abstract
Purpose To resolve the shortage of donor lungs, the use of non-heart-beating donors (NHBD) has come into practice. An ideal method of preservation that can improve the quality of NHBD lungs has been investigated. Normothermic ex vivo lung perfusion (EVLP) enables organ viability assessment before transplantation. In this study, we investigated whether NHBD lungs can be resuscitated after warm ischemia by normothermic EVLP. Methods and Materials Four hours after cardiac arrest, the beagles were allocated into 2 groups (n=6 each): static cold storage (SCS) or normothermic EVLP using STEEN solution for 3.5 h. The physiological lung functions were evaluated during normothermic EVLP. In both groups, left lungs were then transplanted and reperfused for 4 h to investigate posttransplant lung functions. Results In each group, one beagle has died due to severe pulmonary edema after 2 h of reperfusion. Lung oxygenation significantly improved with normothermic EVLP (p Conclusions Normothermic ex vivo lung perfusion could resuscitate NHBD lungs injured by 4 h of warm ischemia.
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