Abstract
A growing number of papers have recently investigated changes in interhemispheric connectivity in HD, although little is known about their temporal relation with clinical features and electrophysiological parameters. In this study we evaluated for the first time interhemispheric connectivity in Huntington’s disease (HD) by using a transcranial magnetic stimulation (TMS) protocol. We evaluated ipsilateral silent period (onset latency, iSPOL, and duration, iSPD) and transcallosal conduction time (TCT) in early manifest HD patients compared with sex and age-matched healthy volunteers; then, in HD group, we correlated TMS data with cognitive (MMSE), genetic (CAG-length), and clinical (UHDRS-I) scores. Compared with healthy volunteers, patients showed a marked decrease of iSPD, paralleled by a significant lengthening of iSPOL and TCT ( p p
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