Abstract
The BRCA proteins play a key role in the homologous recombination (HR) pathway. Beyond BRCA1/2, other genes are involved in the HR Repair (HRR). Due to the prominent role in the cellular repair process, deleterious variants in HRR genes may cause inadequate DNA damage repair in cardiomyocytes. The role of BRCA1/2 as predisposing condition to cardiac dysfunction is debated, and the contribution by no-BRCA genes is still unknown.
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Schedule a callMore From: Annals of oncology : official journal of the European Society for Medical Oncology
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