903 Bone Marrow Derived Human Mesenchymal Stem Cells have the Capacity to Differentiate into B-Cells in Vivo

Abstract

S136 Brief Abstract: While fear and anxiety are known elements of the phasesofcancer survivorship,otherperceptionsarenotwellknown.There is a large focus on survivorship in pediatrics, as well as solid tumor malignancies, but this has been an understudied area in adults with leukemia. This is apilot studycomparing races and leukemia subtypes amongdifferent cancer survivorship phases. Full Abstract: Background: The three phases of cancer survivorship include the acute survival phase (ASP), the extended survival phase (ESP), and the permanent survival phase (PSP). This IRB-approved retrospective pilot project compared races and leukemia subtypes among patients in the ASP, ESP, and PSP. Methods: Fifty-five adult patients from our NCI-designated cancer center were individually interviewed. Questions were derived from the PLWC, NCCN, and NRC websites. Subjects were asked about multiple areas of survivorship, including their social support system, distress level, and QOL. Results: Demographics of the 55 patients are ALL-10, AML-9, CLL-23, and CML-13; females-23 and males32; Hispanics-30, Caucasians-20, and African-Americans-5; ASP22, ESP-21, and PSP-12 patients. AML patients experienced the most physical, family, emotional, and spiritual problems (78%, 33%, 56%, and 22%). AML Clinical Lymphoma, Myeloma & Leukemia June 2011 patients also had the highest distress level with a mean score of 5.8 (SD 1.7), compared to ALL (1.8), CLL (3.2), and CML patients (5.1), (p-value 0.001). Among all the phases of survivorship, the ASP had the highest distress level (mean-4.8) and the worst QOL (mean-2.3). The ASP patients had the most treatment for depression (38%). When comparing races, African Americans and Hispanics (40% and 37%) were unable to cope with finances, as compared to Caucasians (5%), (p-value 0.016). Fear of recurrence was higher in Hispanics (67%), compared to African Americans (40%) and Caucasians (30%), (p-value 0.031). African Americans reported requiring more assistance with social and spiritual well-being (40% for each). Hispanics (40%) experienced problems with housing, insurance, and work, as compared to African Americans (20%) and Caucasians (10%), (p-value 0.047). Conclusion: This pilot study addresses the perceptions and beliefs of leukemia survivors and found that AML and minority patients need further investigation on various aspects of QOL. More studies should be done in adult leukemia patients to overcome the hurdles to optimal cancer survivorship care.