Abstract
Wound healing and skin scarring models allow the study of the complex processes of scar formation and wound healing found in the human skin. Models are categorized into in silico, in vitro, ex vivo, and in vivo. The aim of this review is to summarize and evaluate the above models. In silico models allow theoretical application, and in vitro provides vital information regarding skin and cellular interactions; however, translation of findings into in vivo models can be challenging given the lack of multiple confounding factors often encountered in common clinical situations. ex vivo models are useful for testing new therapeutic agents; however, there is a lack of standardization between the protocols used in these studies. Human cutaneous scar and wound models are vital in the understanding of healing physiology and pathophysiology and in the safe assessment of current and emerging wound therapeutics with the ultimate aim of scarring-free skin regeneration.
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