9. The Effectiviteness of Jatropha salve (Jatropha curcas L) in Inflammatory Phase of cutaneous wound healing in Mice (Mus musculus) Histopathologically

Abstract

This study aims to determine the effectiveness of 10% Jatropha salve (Jatropha curcas L. ) to inflammation reaction cutaneous wound healing in m ice (Mus musculus ) in the inflammatory phase. This experiment used 9 male mices, weighing 25-40 grams and age 2-3 months old, were divided into three treatment groups, each treatment consisting of three mices. The wound were made along 2 cms in the back area . Wound therapy was carried out twice a day for 3 days. Group KI was administered and given by yellow v aseline, KII was given 10% Jatropha salve, and KIII was given g entamicin salve . The parameters measured are the increase in the number infiltrations of inflammatory cells, neovascular , and re-epitelization. All quantitative data were measure d using ANOVA and continue d with Duncan Test, the qualitative data were presented descriptively by showing the results of observation under a microscope. The statistical test on the infiltrations of inflammatory cells and neovasculars parameter 10% Jatropha salve group significantly different (P<0.05) compared to KI and KIII group. Histopatologycal observations indicated the 10% Jatropha salve c ould be reduce the infiltrations of inflammatory cells , increase neovasculars and re-epitelization percentage. According to the result can be concluded the 10% Jatropha salve can accelerate the inflammation phase cutaneous wound healing in mice.