Abstract
s / Atherosclerosis 223 (2012) 527–535 530 Methods: ApoE and glycated apoE distributions in different lipoproteins in 32 (18 men and 14 women) healthy volunteers were determined. Results: Total apoE concentration (mean SEM) was 48.2 2.4 mg/l. Of this 13.3 2.5 mg/l (27.6%) was in VLDL, 10.6 2.2 mg/l (22.0%) in LDL, 14.4 1.2 mg/l (29.9%) in HDL and 9.9 2.0 mg/l (20.5%) in the density range >1.21 g/ml. ApoE concentration in VLDL was strongly correlated with VLDL-apoB and VLDL-TG. There was no significant difference in total apoE between men and women. However, in men VLDL-apoE was significantly higher (15.6 1.4 mg/l vs. 10.3 1.4 mg/l, p 1.21 g/ml were glycated. Conclusions: The apoE concentration and lipoproteins distribution are influenced by age and gender. VLDL and LDL apoE are more susceptible to glycation in vivo.
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