Abstract
Since the 1980s when pioneering techniques were developed on the use of limbal tissue transplantation, significant progress has been made on developing limbal stem cell therapies. Ex vivo expansion of autologous progenitor cells has reduced the risk of inducing limbal stem cell deficiency in the donor eye, and the use of novel carriers has improved the logistical ease of the procedure. More recently contact lenses (CLs) have been trialled as a vehicle for ocular stem cell delivery, reducing the risk of cryptogenic and xenogeneic infections. This chapter discusses current approaches to limbal stem cell transplantation, its therapeutic use for limbal stem cell deficiency, and the advantages of CLs as a vehicle for stem cell delivery compared to current methodologies.
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