Abstract
In the title compound, C21H19BrN2O2·C2H6OS, the indole ring system is essentially planar, with a maximum deviation of 0.050 (3) Å for the non-bridgehead C atom adjacent to the N atom. The two cyclohex-2-enone rings adopt half-chair conformations. An intramolecular C—H⋯O hydrogen bond occurs. The solvent molecule exhibits minor disorder of the S atom [site occupancies = 0.8153 (16) and 0.1847 (18)]. In the crystal, molecules are linked by N—H⋯O hydrogen bonds, forming layers parallel to the bc plane.
Highlights
In the title compound, C21H19BrN2O2C2H6OS, the indole ring system is essentially planar, with a maximum deviation of
For recent studies showing that some acridine analogs having aryl and heteroaryl substituents at the ten position on the ring exert potassium-channel-modulating activiy, see: Şimşek et al (2004), Berkan et al (2002)
The cell e.s.d.'s are taken into account individually in the estimation of e.s.d.'s in distances, angles and torsion angles; correlations between e.s.d.'s in cell parameters are only used when they are defined by crystal symmetry
Summary
Of Pharmaceutical Chemistry, 06100 Sihhiye-Ankara, Turkey, bDepartment of Chemistry, Howard University, 525. College Street NW, Washington, DC 20059, USA, and cDepartment of Physics, Faculty of Sciences, Erciyes University, 38039 Kayseri, Turkey. Key indicators: single-crystal X-ray study; T = 123 K; mean (C–C) = 0.004 Å; disorder in solvent or counterion; R factor = 0.052; wR factor = 0.137; data-toparameter ratio = 15.3. C21H19BrN2O2C2H6OS, the indole ring system is essentially planar, with a maximum deviation of. The two cyclohex-2-enone rings adopt half-chair conformations. An intramolecular C—H O hydrogen bond occurs. The solvent molecule exhibits minor disorder of the S atom [site occupancies = 0.8153 (16) and 0.1847 (18)]. Molecules are linked by N—H O hydrogen bonds, forming layers parallel to the bc plane
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