8-Hydroxy-2′-deoxyguanosine and arsenic compounds in urine and serum of a 4-year-old child suffering from acute promyelocytic leukemia during treatment with arsenic trioxide

Abstract

Arsenic trioxide (ATO) is an effective agent for acute promyelocytic leukemia (APL). In this study, the concentrations of dimethylarsinic acid (DMA), monomethylarsonic acid (MMA), As (V), As (III), and 8-hydroxy-2′-deoxyguanosine (8-OHdG) in urine and/or serum of a 4-year-old APL patient were followed during ATO treatment. In comparison with a similar analysis previously published for an 85-year-old APL patient, the levels of arsenic compounds and the percentages of MMA and DMA in the present child patient were lower than those of the old patient. Significant positive correlation of 8-OHdG was observed only with DMA, and not with other arsenic compounds. These results are quite different from those of our previous study on an old APL patient during ATO treatment. When arsenic poisoning is diagnosed, it seems important to take into account the differences in the arsenic metabolism according to the ages of subjects. This study is the first to show the relationship between the levels of 8-OHdG and arsenic compounds in urine of a child APL patient treated with ATO.