Abstract

GIST is the most common mesenchymal tumor of the gastrointestinal tract. Clinical trials or targeted therapies are recommended for c-kit and PDGFRA wild-type GIST patients who are unable to obtain multi-target protein tyrosine kinase inhibitors therapy. Thus, the identification of targetable mutations will gain new insights into the etiology of c-kit and PDGFRA wild-type GIST.

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