8999 Reproductive Outcomes and Overall Prognosis of Patients with Asherman's Syndrome Undergoing IVF Cycles

Abstract

<h3>Study Objective</h3> To estimate the impact of Asherman's Syndrome (AS) following hysteroscopic adhesiolysis on short term reproductive outcomes and the time to achieve pregnancy in infertile patients during IVF cycles. <h3>Design</h3> Retrospective cohort study. <h3>Setting</h3> Tertiary university affiliated medical center. <h3>Patients or Participants</h3> Fifty-one infertile patients who were treated for Asherman's syndrome (AS) and underwent IVF cycles (study group). Patients were matched with controls in a 1:1 ratio, according to their age and etiology of infertility (control group). <h3>Interventions</h3> The collected date was obtained from medical records and telephonic survey. <h3>Measurements and Main Results</h3> There was no difference in the mean number of embryo transfer per patient between the two groups (4.9 ±4.6 vs. 6.22 ±4.3, p=0.78). The mean endometrial thickness before embryo transfer was significantly higher among women in the control group (8.7 ±1.8 vs. 6.95±1.7, respectively, p=0.001). Women with AS had significantly lower cumulative live birth rate and significantly higher miscarriage rate as compared to women in the control group (23.5% vs 56.8, p=0.001 and 41% vs. 15.6%, p=0.008 accordingly). The mean endometrial thickness was significantly higher among women with AS who had live birth (8.2 (±1.4) 6.9 (±1.2), p=0.001). The Overall time to conception was significantly longer among with AS (407.962 ±74.7 Vs 785.6 <h3>Conclusion</h3> AS has an impact on the reproductive potential in infertile patients following hysteroscopic adhesiolysis. Endometrial thickness was shown to be an important predictor for live birth among women with AS that utilizing IVF.