Abstract

ARID1A, a gene that encodes a subunit of the BAF (SWI/SNF) chromatin remodeling complex. Previous research on the ARID1A gene revealed that ARID1A deficiency was associated with a higher tumor mutation burden (TMB) level and mismatch repair (MMR) in cancer, which might cooperate with immune checkpoint blockade therapy. However, the features of ARID1A, its correlation with immunogenic marker, and the predictive value of immunotherapy for head and neck cancer remain unknown.

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