893 FUNCTIONAL ASSESSMENT OF INTERMEDIATE CORONARY ARTERY STENOSIS

Abstract

Abstract Background FFR represents the gold standard to functionally assess the ischemic potential of intermediate coronary artery stenoses particularly in patients presenting with multivessel disease. However, it is still underused in the current practice. Less invasive techniques have been identified for the evaluation of intermediate stenosis. The Quantitative flow ratio (QFR), based on the angiography with 3D-reconstruction of the coronary artery and computational fluid dynamics, has been showed to well correlate with the FFR. The Angiography-DeriveD hEmoDynamic index (ADDED Index) has also been validated to assess the ischemic potential of intermediate coronary stenosis and was also found to well correlate with FFR. It considers the jeopardized subtended myocardium and the minimal lumen diameter calculated at the angiography. This study aimed to compare the ADDED Index with QFR in terms of diagnostic accuracy. Methods A retrospective observational study was conducted. We included all patients presenting with an intermediate stenosis assessed with QFR. Both QFR and ADDED Index were calculated. Correlation was studied using Pearson's r test and linear regression. Receiver operator characteristics curve analysis was also performed. Results A total of 54 patients presenting with either stable angina or acute coronary syndromes were enrolled and finally 62 intermediate stenoses were included. A significant correlation between the ADDED Index and QFR was found (r2=0,32, p <0.001) (Figure 1). At ROC analysis, and with the QFR as reference, the ADDED Index showed a significant and very high area under the curve (0.99 (0.99-1.00), p<0.001), Figure 2) suggesting the high accuracy for the assessment of the ischemic potential of intermediate coronary artery stenoses. Conclusion ADDED Index was found similar to the QFR in terms of accuracy for the functional assessment of intermediate coronary artery stenoses.