Abstract
Seborrhea is a common cosmetic issue that occurs when oversized sebaceous glands produce excessive amounts of sebum, giving the appearance of shiny and greasy skin. Sebum is made and secreted by sebaceous glands, via the differentiation and disintegration of fully mature sebocytes, a unique process termed holocrine secretion. Moreover, skin oiliness may vary according to diet, age, hot humid climates and ethnicity. Depending on new researches, ethnicity had no significant impact on level of residual skin surface components derived from sebum but, could affect sebum quality (composition and components oxidation). Convinced by the interest to act on the genesis of the sebum secretion mechanism, we have developed a new sebosuppressive agent able to modulate sebocytes differentiation, and also sebum quality. The natural Australian extract selected has been isolated from Backhousia citriodora (Lemon Myrtle leaf). Conforming its promise, Lemon myrtle extract tested on human sebocytes decrease by 32% Epithelial Membrane Antigen expression (marker of sebocyte differentiation) and so by 30% the lipid accumulation in the cytoplasm. Furthermore, two clinical studies validate Lemon Myrtle efficacy. On one hand, at 15 and 30 days, Lemon Myrtle treatment decreases significantly skin sebum content (-17% and -31% respectively) and thus surface covered by oily spots (-17% and -22% respectively). On the other hand, a sebum lipodimic analysis on ethnic volunteers (Caucasian, Asian and African-American) demonstrates that Lemon Myrtle regulates sebum composition and protects its components from oxidation. This natural extract has proven its efficiency to modulate human sebaceous terminal differentiation, characterized by cell changes, lipid droplets accumulation, nuclear degeneration and excess sebum production. Therefore, Lemon Myrtle extract is a promising sebo-regulator to act at the genesis of sebum production and to regulate sebum quality whatever the ethnicity.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
