Abstract
G A A b st ra ct s no significant difference in pancreatic MPO (unit mg of protein) in wild type 2981+734; CB(-/-)3042+767;T7(-/-) 3070+292 (P.0.05) treated with L-arginine, but it was significantly higher compared to saline treated animals(149+12). We also did not find a significant difference in lung MPO in unit /mg of protein in (Wild type 7766+1852; CB(-/)6234+602 and T7(-/-)7185+1236 treated with L-arginine HCL(P .0.05) but significantly higher than saline treated(2555+285) animals. These findings correlate with our finding in cerulein model of acute pancreatitis. Conclusion: Regardless of the model of acute pancreatitis trypsinogen activation significantly decreases acinar cell necrosis, but local and systemic inflammation is independent of trypsin activation.
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