Abstract
The incidence of differentiated thyroid carcinoma (DTC) is increasing in most developed countries. The only well-known risk factor for thyroid cancer is exposure to ionising radiation. DTC is characterised by a strong hereditability, and individual susceptibility is likely due to genetic factors modulating the environmental risk. Identification of genetic polymorphisms is important for understanding the potential mechanisms involved in thyroid carcinogenesis. In this Review, we assess epidemiological data on the role of germ-line DNA polymorphisms and the risk of DTC. We have included only case–control studies that compare the incidence of germ-line mutations in patients with DTC, with the incidence of mutations in patients without a history of DTC. Such an analysis of genetic susceptibility in differentiated thyroid cancer has not yet been published.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
