Abstract
To ascertain that the sexual dimorphism of liver GH receptors in rats is not due to differences in their occupancy by endogenous GH, specific 125I-bovine GH binding was determined on homogenates from male and female animals, before and after MgCl2 treatment to remove endogenous GH. In both sexes total and free GH binding increased with age (table). In 3 day-old rats free receptors were low and increased slightly after HgCl2. Until 3 weeks of age, no sex difference was present. In adult rats, however, female animals had more GH receptors than males, whether endogenous GH was removed or not.In conclusion : 1) in neonatal rats, the low GH binding is not due to occupancy by GH; 2) in adult rats, the sexual dimorphism of GH binding is not due to differences in occupancy by GH.
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