86-LB: Elevated First-Trimester Neutrophil Count Is Associated with the Development of Gestational Diabetes Mellitus in Pregnant Women

Abstract

Aims: Chronic low-grade inflammation is an important cause of systemic insulin resistance and play a central role in the pathophysiology of gestational diabetes mellitus (GDM). This study aimed to investigate the correlation between neutrophil(N) in first-trimester pregnancy and the development of GDM. Methods: 258 women with GDM and 1412 women without GDM were included in this retrospective study. Demographic, pregnancy variables, white blood cell(WBC), neutrophil(N) counts, Neutrophil-to-Lymphocyte Ratio(NLR), clinical biochemical characteristics, delivery information were got from all subjects. Logistic regression analysis with forward stepwise selection were used to determine the independent risk factors for the development of GDM. Result: GDM patients had much higher level of blood glucose(BG), triglyceride(TG), fetal birth weight, WBC, N counts and NLR than women without GDM. There were significant positive association between N counts and 1-hour BG, 2 hour BG, glycosylated hemoglobin(HbA1c), pregnancy body mass index(BMI), and homeostasis model assessment for insulin resistance(HOMA-IR). Additionally, there were significant negative association between N and quantitative insulin sensitivity check index (QUICKI) and low-density lipoprotein(LDL) cholesterol. After adjusting confounding variables, we found N counts was an independent factor for the development of GDM (OR = 1.35; 95% confidence interval, 1.08 to 1.69), regardless the history of GDM (OR = 1.32 for without GDM history). Conclusion: N counts in first-trimester pregnancy is closely associated with the development of GDM in pregnant women. Disclosure T. Sun: None. F. Meng: None. R. Zhang: None. Z. Yu: None. S. Zang: None. J. Liu: None. M. Yang: None. Funding Shanghai Fifth People’s Hospital Research Project Plan; Minhang District Natural Science Research