868P System biology approach to normal tissue protection in cytotoxic cancer therapy: Experimentally validated gene/signaling basis – melanoma as case study

Abstract

About 20% of human population recovers from asymptomatic malignancy without treatment, this process is known as spontaneous regression of tumors. There the host has effective immune system, eliminating tumor cells, but protecting normal tissue. Here we develop systems biology approach for analyzing normal tissue protection process, synchronized with tumor regression. We validate our approach by experimental findings.