Abstract
Ocular neovascularization is the major landmark of several common retinal and choroidal blinding diseases including proliferative diabetic retinopathy and age-related macular degeneration, for which no effective therapy is currently available. Recently we have observed that the Sonic Hedgehog (Shh) pathway is activated in animal models of retinal and choroidal neovascularization and that its pharmacological inhibition results in significant reduction of neovascularization in both models, suggesting this pathway as a new molecular target for treatment of ocular neovascular diseases.
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