867 Superficial soft tissue sarcomas of the adults

Abstract

A series of 105 consecutive patients with superficial soft tissue sarcomas was analysed to assess the evolution of these tumors. There were 56 men and 49 women, aged 16 to 80 years (median: 56.4 years). Tumor localizations were 59 limbs (56.2%) and 41 non-limbs. The median tumor size was 3cm (range 1 to 15cm). Histological types were mainly malignant fibrous histiocyto-fibromas (n=39/36.8%), leiomyosarcomas (n=20/18.9%), dermatofibrosarcomas protuberous (n=8/7.5%). According to the FNCLCC grading, tumor grade was: grade 3=24, grade 2=54, grade 1=28. With a median follow-up of 112 months (range 19 to 321 months), the 5-year overall and disease-free survival were 75% and 46%. In mono-factorial analysis, tumor grade is the only predictive factor for overall survival (grade 1 vs grade 2: <i>P</i>=0.02; grade 2 vs grade 3: P=0.0002), and for metastasis-free survival (grade 1 vs grade 2: <i>P</i>=0.05; grade 2 vs grade 3: <i>P</i>=0.0006). For grade 2 tumors, metastases occurred only after a deep, local recurrence. Age, tumor size, tumor localizations were not statistically significant. For the local relapse-free survival, tumor size (<5 vs ≥5cm) was the only predictive factor (<i>P</i>=0.0006).