865P TNFRSF1B gene variants on susceptibility, clinicopathological aspects, and prognosis of patients with cutaneous melanoma

Abstract

Regulatory T lymphocytes (Treg) modulate the destruction of abnormal cells through the binding of tumor necrosis factor (TNF) to tumor necrosis factor receptor 2 (TNFR2) on its surface. The TNFR2 is encoded by the TNFRSF1B polymorphic gene, and therefore, healthy individuals may be at distinct risks of CM and CM patients may have tumors of different behaviors. This study aimed to evaluate the roles of TNFRSF1B c.587T>G, c.*188A>G, c.*215C>T, and c.*922C>T single nucleotide variants (SNVs) in risk, clinicopathological aspects, and survival of CM patients.