Abstract
exposition in patients after pouch surgery (pouch patients versus IBD patients, p < 0.02). Conclusions:Increased cell shedding and transient epithelial cell destruction with subsequent bacterial translocation are newly discovered features of IBD pathophysiology. These changes can be identified and quantified in humans during ongoing colonoscopy using CLE. This might further support the notion that intrinsic micro-flora can trigger flares in patients with IBD. Thus, CLE might play a crucial role in the future for monitoring mucosal healing in patients with IBD. Epithelial changes of the terminal ileum before and after the exposition of rectal micro-flora
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