Abstract
Inflammatory and homeostatic chemokines (CKs) and chemokine receptors (CKRs) affect T-cell homing after heart transplantation (HTx). We investigated circulating T-cell CKR and intragraft CK and CKR levels from cardiac allograft recipients in relation to endomyocardial biopsy (EMB) rejection grade. Twenty HTx recipients under calcineurin inhibitors, prednisone and MMF were studied prospectively at 1, 2, 3, 4, 12, 24 and 38 weeks post-HTx. Peripheral blood samples were collected during the EMB procedure and cell surface inflammatory (CCR5 & CXCR3) and homeostatic (CCR7) CKR expression on CD4+ and CD8+ T-cell subsets was measured by whole blood flow cytometry.
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