Abstract

While immune checkpoint inhibitors (ICI) have revolutionized treatment of metastatic melanoma (MM) patients, still 40–60% of patients do not achieve a clinical benefit. Tissue-based predictive biomarkers are not validated in MM, and non-invasive liquid biomarkers can be an alternative source. Whole-blood transcriptome has shown to identify early response to ICI in urothelial cancer, thus have a potential in the context of MM.

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