855 Cutaneous transcriptomics identifies fibroproliferative and neurovascular gene dysregulation in prurigo nodularis compared to psoriasis and atopic dermatitis

Abstract

Prurigo nodularis (PN) is a chronic inflammatory skin disease that is associated with several systemic comorbidities, suggesting dysregulation of cutaneous and systemic inflammatory processes. Th2, 17, and 22 immune signatures have been identified in PN lesions, highlighting shared cutaneous gene signatures between PN, psoriasis (PsO), and atopic dermatitis (AD). We aimed to identify pathways specific to PN by comparing the skin transcriptomes of PN, PsO, and AD. RNA-seq was performed on lesional and nonlesional biopsies from PN patients without a history of atopy or PsO.