851 Cancer associated fibroblasts in different T-stage lesions of cutaneous T-cell lymphoma

Abstract

The tumor microenvironment (TME) has been shown to play an important role in tumor initiation, development, and metastasis. Among all TME factors, cancer associated fibroblasts (CAF) have been suggested to play a key role. Two studies have reported that fibroblasts from cutaneous T-cell lymphoma (CTCL) lesions, mycosis fungoides (MF) and/or Sézary syndrome (SS), were hyper-activated and exerted a pro-tumorigenic activity on CTCL cells in vitro. But much regarding CAFs in development of CTCL remains to be understood.