Abstract
Acute lymphoblastic leukemia is one among the common paediatric malignancies. CNS relapse is the major concern in treatment of ALL because of inability of chemotherapy to cross the blood-brain barrier. CNS directed treatments include prophylactic cranial irradiation (PCI), intrathecal methotrexate (ITMTX) and high dose systemic therapy. A combination of PCI and IT MTX is the most commonly used CNS directed therapy. PCI is associated with neurocognitive side effects, memory and attention deficits.
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